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Chronic inflammation in the etiology of disease across the life span

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Acne localization and severity Tends to affect androgen-sensitive areas like the face, chest, upper back, and arms Is generally mild Severe inflammatory cystic acne is less common Up to 94% may experience acne per some studies Those at highest risk are: Transgender patients receiving masculinizing doses Teens taking testosterone for short stature Bodybuilders abusing anabolic steroids Are Acne Issues Common with Testosterone Replacement Therapy

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Reversion: If treatments are discontinued, melanin production gradually returns to normal levels, potentially reversing whitening effects over time

doi:10.1016/j.autrev.2009.02.020