Option 3: Reduce dose
Under chronic stress conditions, dysbiosis in the gut microbiota can lead to HPAA dysfunction and abnormal increases in cortisol secretion (Zinkow et al., 2024)
SpringerY Fogelman, Kitai E, Blumberg G, Golan-Cohen A, Rapoport M (2017) E CarmeliAging clinical and experimental research, 2017Springer 29:135139 Damio CP, Rodrigues AO, Pinheiro MFMC, Da Cruz Filho RA, Cardoso GP, Taboada GF, Lima GAB (2016) Prevalence of vitamin B12 deficiency in type 2 diabetic patients using metformin: a cross-sectional study
Rapamycin-mediated lifespan increase in mice is dose and sex dependent and metabolically distinct from dietary restriction

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Including active recovery in a fitness routine, such as foam rolling, stretching, or contrast therapy, are helpful for maintaining health and function