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462,468 Topical calcineurin inhibitors (TCIs) have substantial anti-inflammatory effects, inhibiting the biosynthesis of proinflammatory cytokines by T cells and mast cells, as well as antipruritic effects that are attributed to specific effects on skin Transient receptor potential vanilloid 1 (TRPV1) neurons

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With a separated batch of animals, established identically, blood cell analysis and hematoxylin-eosin staining (HE) of organs was completed

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With an estimated prevalence of over a billion subjects affected, even among lean children, approximately 10 % (Nobili and Pinzani 2010[108]