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Inhibition of ferroptosis to alleviate renal fibrosis: Studies indicate that targeting ferroptosis specifically with certain inhibitors can mitigate kidney damage and renal fibrosis: (1) In a 5/6 nephrectomy-induced CKD rat model, deferoxamine alleviates kidney injury and fibrosis by regulating iron metabolism and the TGF-1/Smad3 pathway (199)

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PKD3 has been implicated in tumor progression and invasiveness in breast and gastric cancers, as well as hepatocellular carcinoma (Huck et al, 2014

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