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Depending on the severity and reversibility of these interconnected events, PACs may undergo adaptive recovery, apoptosis, or necrotic cell death, whereas extensive and self-sustaining organellar disintegration contributes to tissue injury, systemic inflammation, multiple organ dysfunction, and the severe clinical course of AP

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To identify specific genes that evolved within the Ajellomycetaceae to enable the dimorphic transition and infection of mammals, we identified and examined ortholog clusters that were unique to these pathogens and absent in both H

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Nov 17: AstraZeneca scored a first-in-class approval for its pan-AKT inhibitor capivasertib as a treatment for adults with hormone receptorpositive and HER2-negative locally advanced or metastatic breast cancer whose tumors also have PIK3CA, AKT1 or PTEN mutations