Although symptoms are included in the definition of PD, it should be recognized that the base definition of PD is fibrosis
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doi: 10.1126/scitranslmed.aay3069
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The idea of over-firing due to extra receptors is speculative
As the main transcription factor of Th17 cell, RORt collaborates with other transcription factors, such as ROR, IRF4, and Runx1, to synergistically stimulate Th17 cell growth and IL-17 release ( Foxp3 interacts with several transcription factors, such as STAT5, NFAT, and BACH2, to influence the Treg cells' development, stability, and epigenetic modifications
