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Moreover, elevated AR activity may impair antioxidant defences through NADPH depletion, thereby limiting glutathione (GSH) regeneration and exacerbating oxidative stress 10,52 ( Figure 7 )

doi: 10.1371/journal.ppat.1011371 82 FongGHTakedaK

Chronic low-dose exposure to a mixture of environmental endocrine disruptors induces microRNAs/isomiRs deregulation in mouse concomitant with intratesticular estradiol reduction

Interestingly, the expression of GHR and IGF-1 were reduced in the skeletal muscle of these animals