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This means the B12 component in a compounded semaglutide formulation is most likely to help patients who are deficient or at risk of deficiency, those eating very little, those following plant-based diets, older adults whose B12 absorption decreases with age, or those with conditions affecting B12 absorption like gastric bypass or certain GI conditions

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Nat Biotechnol 19:10671070 Yang XW, Model P, Heintz N (1997) Homologous recombination based modification in Escherichia coli and germline transmission in transgenic mice of a bacterial artificial chromosome