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3.4 Changes in serum homocysteine by supplementation route and dosage Analysis of 10 comparisons showed that vitamin B12 supplementation was associated with a mean reduction of 35.8% in serum homocysteine concentrations (Supplementary Table S5)

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Pernicious Anemia: Parenteral vitamin B 12is the recommended treatment and will be required for the remainder of the patient's life

(85 g) provides 93% of the DV (22,27)

Primary Handling Editor: Sonia Muliyil, in collaboration with the Nature Medicine team