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Results TM16-TM17 of MRP1 are essential for the GSH-dependent transport of drugs but not for the basal transport of GSH We undertook to dissect the particular mechanism of massive GSH efflux by studying the implication of the different parts of the transporter MRP1 in this phenomenon and to discriminate the regions in MRP1 that selectively control the stimulated mode of transport of GSH from the basal transport of GSH by using MRP1/MRP2 chimeras