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Histone deacetylases (HDACs) are epigenetic regulators that modulate gene expression by removing acetyl groups from lysine residues on proteins, affecting processes like cell proliferation, differentiation, and development

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We eliminated 23 records out of 123 articles as they were not relevant to the topic, making the 100th most cited article the 123rd on the list

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It would be useful if one could develop an asymmetric vesicle system with cholesterol, with defined species of both a glycosphingolipid such as Gb3 in the outer leaflet and PS in the inner leaflet and include a reporter kinase to determine whether crosslinking of Gb3 could induce a transmembrane signalling similarly to what was reported by Iwabuchi et al