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Biochem 66 , 6192 (1997)

This limitation is expected to be addressed by a dedicated two-phased validation strategy in future work: Phase I Retrospective RNA Validation: This involves prioritizing an intensive search for and inclusion of any suitable independent external RNA-seq cohorts with adequate clinical follow-up data

Cooperative binding is at the center of this regulation, whereby the binding of oxygen to one heme group makes the other heme groups in a better position to bind with oxygen (35)

Bohnen NI, Kotagal V, Mller MLTM, Koeppe RA, Scott PJH, Albin RL, et al

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Nozik-Grayck E, Suliman HB, Majka S et al (2008) Lung EC-SOD overexpression attenuates hypoxic induction of Egr-1 and chronic hypoxic pulmonary vascular remodeling