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Conversely, another study [271], showed that adding m 1 -modified mRNA to whole human blood samples did not stimulate IL-12 secretion but did upregulate TNF- and IL-6, regardless of whether chromatographic purification was performed

However, rather than viewing NF-B modulation and microbiota-targeted therapies as mutually exclusive strategies, a synergistic approach integrating both avenues may offer greater therapeutic efficacy