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The loss of SLC7A11 and SLC3A2 has been shown to promote cancer cell survival under glucose starvation conditions and SLC7A11 overexpression promotes glucose starvation-induced cell death and vice versa ( Figure 2 )

A delicate balance between dormant and actively developing follicles, regulating factors that influence follicular growth, and selecting one follicle for mature ovulation define the ovaries anatomy and physiology [37]

This is clearly an area in need of more research.

doi: 10.1007/s11064-021-03442-7 106 AbdulYLiWWardRAbdelsaidMHafezSDongGet al

The gold standard for in vivo PCOS research is the letrozole-induced PCOS rat model, in which female Sprague-Dawley rats (4-6 weeks old) received letrozole (1 mg/kg PO once daily) for 21 days (3,20,21)