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Specifically, selenomethionine confers ferroptosis protection through two distinct pathways : (1) a GPX4-dependent mechanism involving selenium provision via multiple metabolic routes to sustain GPX4 biosynthesis, and (2) a GPX4-independent mechanism mediated through direct ROS scavenging via its intrinsic redox-active properties

By employing whole-genome haploid screening and CRISPR-Cas9 technology, two pivotal drivers of ferroptosis were identified: Acyl-CoA synthetase long-chain family member 4 (ACSL4) and lysophosphatidylcholine acyltransferase 3 (LPCAT3), both of which function as membrane remodeling enzymes [75,76,77]

2a,b) and an upwards movement of the side chain of phenylalanine F112 (Fig

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Sterile water lacks the preservative (benzyl alcohol) that prevents bacterial growth