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Notably, the three-dimensional structure indicates that OsDHAR contains a broad, uncharged cleft between the 2-helix and the 3-helix as the putative binding site for non-native protein folding intermediates for its chaperone-like activity

Therefore, it is logical to suggest that synaptic dysfunctions occur in individuals with SLOS

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The changes were similar to what was observed in the cagrilintide and semaglutide groups