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2012), and several strategies have been introduced to improve their safety profile, including directing integration to heterochromatin regions of the genome, introduction of self-inactivating mutations, production of non-integrating lentivectors and, more recently, removal of a sequence element involved in plus-strand DNA synthesis shown to further reduce integration and increase the efficiency of formation of circular episomes (Apolonia et al

Fetal dopaminergic transplantation trials and the future of neural grafting in Parkinsons disease

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The interplay between cytokines, inflammation, and antioxidants: mechanistic insights and therapeutic potentials of various antioxidants and anti-cytokine compounds

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