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Int J Endocrinol (2015) 2015:849615.10.1155/2015/849615 105 ChngCLJonesMKKinghamJG

For example, active or passive smoking induces oxidative stress and systemic inflammation, impairing ovarian function and insulin sensitivity, thereby exacerbating metabolic and reproductive dysfunction in PCOS (21)

miR-200a regulates Nrf2 activation by targeting Keap1 mRNA in breast cancer cells

Because NF-B in turn activates many pro-inflammatory cytokines, this mechanism could contribute to increased inflammation and cytokine storms observed in COVID-19

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Its mechanism is purely metabolic: it directly targets lipid metabolism via inhibition of NNMT and restoration of cellular NAD+