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However, chronic administration of MAGL inhibitors can lead to desensitization of CB1 receptors [52], suggesting that dosing and duration of administration would need to be carefully considered

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We found no correlations between CAPS-5 scores and plasma concentrations of JNJ-42165279 at week 8 (r s [23] = 0.25, p = 0.24) nor at week 12 (r s [28] = 0.042, p = 0.83)

40.4% of CagriSema patients achieved 25% or more weight loss, whereas only 16.2% of Semaglutide patients hit that threshold, and a mere 6.0% of Cagrilintide monotherapy patients got there