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Redox-dependent modulation of aconitase activity in intact mitochondria

For example, a mouse model showed a 45% drop in the GSH/GSSG (glutathione disulfide) ratio after just one week of urban air exposure, alongside increased markers of oxidative stress like lipid peroxidation and protein carbonyls

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When addressing dimeric protein targets, the ability of dimeric therapeutic agents to antagonize paired receptors within a single molecular entity potentially offers superior therapeutic efficacy and target selectivity 15,16

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