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XL wrote the first draft of the manuscript

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The reaction was initiated by mixing 2035 g protein with a reaction mixture containing 10 mM ATP, 5 mM L-cysteine, 50 mM L-glutamate, 500 M acivicin, 20 mM MgCl 2 , 100 mM Tris-HCl pH 8.2 in a total volume of 150 l followed by incubation for 15 min at 25C

doi: 10.1159/000360101 154

The IRS2 Gly1057Asp variant is associated with human longevity

Acknowledgements The authors are supported by National Institutes of Health (NIH) grants R33HL154252, R01EY035853 and U54CA268083 (P.C.S.), and VA RSF Banks.025 (W.A.B.)