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Conclusion: Our study demonstrates a central role of alcohol-induced BTK activation in regulating steatosis, inflammation, NLRP3 inflammasome activation and NETs formation in AH by acting on both hepatocytes and immune cells

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In PCOS, where OS, androgen excess, and IR coalesce, melatonin re-establishes a synchronized endocrine rhythm, offering both mechanistic and therapeutic promise as part of a redox-endocrine restoration strategy

Most antioxidant enzymes contain redox-sensitive gene regulatory sequences in their promoter and/or intron regions that can interact with transcription factors to trigger upregulation of gene expression (13)