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A consistent model goes with ligation leading to vessel injury, exposure of tissue factors, stasis, thrombosis, hemodynamic changes, arterial hypotension, and in particular, venous hypertension, which approximates values over 20 mm Hg in the inferior caval vein, 101 thereby being roughly four times higher than those in normal rats

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The good news is that these side effects typically peak in the first 1 to 2 weeks after a dose increase and then diminish as your body adjusts