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A wide range of additional mediators that trigger EMT through TGF-1 activation have been described, including hypoxia-mediated ROS, Fibroblast Growth Factor-2 (FGF-2), Epidermal Growth Factor (EGF), CTGF and Transglutaminase 2 (TG2) [241,242,243,244] (Fig

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Also preferred is an isolated polypeptide comprising an amino acid sequence at least 95% identical to a sequence of at least about 30 contiguous amino acids in the amino acid sequence of the protein encoded by a cDNA clone identified by a cDNA Clone Identifier in Table I and contained in the deposit with the ATCC Deposit Number shown for said cDNA clone in Table I