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Insofar as GAD autoantibodies are detected early in nearly all T1D, the logical segue was that islets would be depleted of the product of this enzyme, namely, GABA

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UA can be synthesized into polyursolic acid (PUA) by polycondensation reaction, and the self-assembly of this PUA with paclitaxel can form PUA-NPs@PTX nanoparticles, and this PUA-NPs@PTX can be retained for a longer period of time in CT26 hormone mice, which has strong anti-tumor effects on colon cancer (CT26) cells [1084]

At higher levels or