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In Bca cells treated with brusatol, CHAC1 expression significantly rises, leading to GSH depletion, ROS buildup, and increased lipid peroxidation, which are key features of ferroptosis

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doi: 10.1186/s12943-020-01247-w 271 AmouzegarAChelvanambiMFildermanJNStorkusWJLukeJJ

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Aquaporin-3 controls breast cancer cell migration by regulating hydrogen peroxide transport and its downstream cell signaling

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First, while antibiotic suppression is used to invoke a role for gut microbiota in the generation of the metabolite(s) monitored, antibiotics can also have direct effects on the host, altering normal metabolism (57, 58)

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Int Endod J 52:11281137

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