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It is possible that mutation of the iron-binding histidines changes the tertiary structure of CDO in such a way that it is no longer recognized by an ubiquitin ligase, resulting in the disruption of cysteine-sensitive ubiquitination and degradation

Bose J, Rodrigo-Moreno A, Shabala S (2014) ROS homeostasis in halophytes in the context of salinity stress tolerance

In pathological conditions, astrocytes undergo significant molecular and morphological remodeling, adopting either a detrimental A1 (neurotoxic) or beneficial A2 (neuroprotective) reactive state that, respectively, drives injury progression or promotes tissue repair [132, 133]

Guldbrandsen N, Mieri M, Gupta M, Seiser T, Wiebe C, Dickhaut J, Reingruber R, Oliver SMH (2015) Screening of panamanian plant extracts for pesticidal properties and Hplc-based identification of active compounds

Passaro A, Mok T, Peters S, Popat S, Ahn M, De Marinis F

This allows the body to absorb glutathione efficiently to support detoxification, immune health, skin clarity, and cellular repair