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A large 2022 New Zealand cohort study (N = 31,907) demonstrated that, among males with gout and no history of CVD, regular urate-lowering medicine dispensing and treatment of serum urate to target levels was associated with a lower risk of cardiovascular events

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HOAc, RT, (d) R 3 = TBDMS, 0.5-1 M aq HCI (e) EDCI, HOBt, NH 2 -(CH 2 )n-CONH 2 [0227] The alkoxy-carbonyl bearing an amino group can also be introduced at the C-terminal amide, which following esterase mediated bioconversion should regenerate A2

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