M.FishmanR
Controlled human trials exist, but they're limited in size, focused mostly on topical cosmetic use, and usually last only a few weeks or months. That means a lot of the exciting claims, especially around gene expression, systemic repair, and anti-aging effects, haven't been confirmed in large-scale human studies
Over the past 15 years, the field of chemical protein modification has been dramatically revitalized, from one that focused on the use of natural cysteine and lysine residues to one that now utilizes a wide range of chemical handles, coupling partners and conditions, many of which are mutually compatible (orthogonal) not just with (to) each other, thereby allowing multiple modifications to be undertaken, but also with (to) living systems, allowing them to be utilized in vivo 170
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