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Data were expressed as permeability (Papp) calculated using the following formula: where dQ/dt, rate of permeation C 0 , initial concentration of compound A, area of monolayer (0.11 cm 2 ) Efflux Ratio (R e ) was calculated using the formula: 5.2

Effect of Naltrexone-Bupropion on Major Adverse Cardiovascular Events in Overweight and Obese Patients with Cardiovascular Risk Factors: A Randomized Clinical Trial