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Secondly, in the DKA state, the body prioritizes various metabolic emergency mechanisms to maintain vital signs stability, such as increasing gluconeogenesis, lipolysis, and ketone body production

4.6.4 Neuroinflammation Central and systemic inflammation play a role in ALS pathogenesis, with some immune cell targets [8, 233] leading to investigational considerations (Table 4)

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Modelling of the point mutations within the DHFR crystal structure suggested that E173D contributes to a higher conformational flexibility and increases the exposure of Lys side chains on the surface under elevated temperatures

in Annual Reports in Medicinal Chemistry, Vol 50: Platform Technologies in Drug Discovery and Validation Vol