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Oestrogen-receptor-positive breast tumours harbouring a sporadic NF1 mutation have a poor outcome, 90 and depletion of oestrogen through ovariectomy in a NF1 -loss-driven rat model of breast cancer leads to tumour regression

Margonis K, Fatouros IG, Jamurtas AZ, Nikolaidis MG, Douroudos I, Chatzinikolaou A, et al

The peptide's potential to mimic BDNF-like activity underscores its therapeutic interest in neurodegenerative diseases and cognitive disorders

Enhancement of activities relative to fatty acid oxidation in the liver of rats depleted of L-carnitine by D-carnitine and a gamma-butyrobetaine hydroxylase inhibitor

Sun J, Wang F, Ling Z, Yu X, Chen W, Li H, Jin J, Pang M et al (2016) Clostridium butyricum attenuates cerebral ischemia/reperfusion injury in diabetic mice via modulation of gut microbiota

GRAS simply means the FDA agrees that the substance, at intended use levels as a food additive or supplement, is safe based on common use history or expert opinion and does not pose acute toxicity concerns