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Recent developments, including the use of exosomes and gene-editing technologies, have expanded therapeutic options for OA, demonstrating efficacy across cellular, animal, and clinical models

Oxidation leads to inflammation

Here, we focused primarily on the acute mitochondrial impact of 5FU, and although we arrived at the combination of 5FU and mitochondrial inhibitors (more specifically, 5FU and metformin) somewhat serendipitously, we have now generated evidence to support the use of 5FU and metformin combinations not only in patients with resistant or relapsed disease as previously suggested by others, but also in treatment-naive, first-line chemotherapy settings

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This finding indicates that in the minimal in vitro reconstitution system the two sites act cooperatively rather than independently: loss of one site compromises the ability of the other to promote activation