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Horm Res 40 : 6267 Mauras N (1995) Combined recombinant human growth hormone and recombinant human insulin-like growth factor I: lack of synergy on whole body protein anabolism in normally fed subjects

[7] So the honest one-line summary is that both build on GLP-1 but recruit a different second pathway amylin for CagriSema, GIP for tirzepatide and there is a further structural difference underneath that: CagriSema achieves its dual action with two separate peptides, while tirzepatide achieves its dual action with one

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Drug Design, Development and Therapy [Internet]