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doi:10.1002/cpt.173

Similarly, targeting other metabolic complexes or enzymes is restricted by their toxicity to normal tissues

Additionally, HIF-1 supports the maintenance of GSCs by upregulating stemness-associated genes such as KLF4, MYC, OCT4, SOX2, and NANOG, sustaining their self-renewal and resistance to conventional therapies

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Decreased Expression of the Long Non-Coding RNA SLC7A11-AS1 Predicts Poor Prognosis and Promotes Tumor Growth in Gastric Cancer

Findings that production of inflammatory mediators correlates directly with altered lung function suggests that they play a key role in toxicity