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4,11,15 Inflammatory responses mediated by proinflammatory cytokines and pathways, such as nuclear factor kappa B (NF-B) and Toll-like receptor 4 (TLR4), worsen the condition by amplifying oxidative stress and hindering neuronal repair

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Low levels of CoQ 10 are characteristic for mitochondriopathies, diabetes mellitus, cancers, cardiovascular and cerebrovascular diseases including but not restricted to the heart failure, myocardial infarction, migraine, chronic kidney disease, and hypertension, neurodegenerative disorders including Alzheimers and Parkinsons disease, and muscular dystrophy