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fumigatus egtA was deleted from strains AfS77 (a akuA::loxP strain derived from ATCC46645 lacking non-homologous recombination 29 ) and ATCC26933 using a split marker strategy 29

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Abbreviations ADL: Activities of daily living ANOVA: Analysis of variance BMI: Body mass index (kg/m 2 , kilograms per meter squared) BML: Bone marrow lesion BMAC: Bone marrow aspirate concentrate DEGs: Differentially expressed genes EKOA: Early-stage knee osteoarthritis HTO: High tibial osteotomy IQR: Interquartile range KOOS: Knee injury and osteoarthritis outcome score MOAKS: Magnetic resonance imaging osteoarthritis knee score MSCs: Mesenchymal stem cells MRI: Magnetic resonance imaging OA: Osteoarthritis OA-BMLs: Osteoarthritis-associated bone marrow lesions OARSI: Osteoarthritis research society international PRP: Platelet-rich plasma QOL: Quality of life SD: Standard deviation SRA: Sport and recreation activities TKA: Total knee arthroplasty TKR: Total knee replacement UKA: Unicompartmental knee arthroplasty VAS: Visual analog scale WOMAC: Western ontario and mcmaster universities osteoarthritis index References Moradi K, Kubassova O, Carrino JA

The delicate redox balance is disrupted when the intracellular reducing environment becomes excessively elevated, resulting in RS