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Mounting evidence from multi-omics studies implicates microbial imbalance in the pathogenesis of diverse disease states, spanning metabolic syndrome, autoimmune disorders, and neuropsychiatric conditions (Li et al., 2022a)

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7.4 Alkaloids: suppressors of apoptosis and metabolic dysfunction Alkaloids attenuate ALD by suppressing the MAPK/NF-B axis, thereby reducing ERK/JNK phosphorylation and TNF- production, which mitigates hepatocyte apoptosis ( Oxymatrine, a quinolizidine alkaloid from the roots of Sophora flavescens Aiton [Fabaceae], inhibits ERK1/2-mediated apoptosis and downregulates pro-inflammatory cytokines ( Berberine, an isoquinoline alkaloid from traditional Chinese medicinal herbs such as Coptis chinensis Franch

Excessively elevated IGF-1 suggests dosing higher than necessary

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A polypeptide is a long, continuous, and unbranched peptide chain