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High to moderate expression is also seen in tissues with metabolic or endocrine functions including pancreas, adrenal gland, thyroid, pituitary gland, skeletal muscle, heart, liver and the gastrointestinal tract and in all regions of the central nervous system examined, including amygdala, hippocampus, substantia nigra, thalamus, cerebellum, cerebral cortex, and spinal cord

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Niacin (vitamin B3) is the precursor to nicotinamide adenine dinucleotide (NAD) and its phosphate form (NADP), coenzymes involved in over 400 enzymatic reactions, particularly those of energy metabolism and the oxidative stress response

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11C-Gln is another PET tracer