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The TEV protease itself, with various mutations used to increase its stability activity, can be readily purified using plasmids found in this paper (available at Addgene)

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(2015) estimated radiation-induced apoptosis in hematopoietic stem cells and progenitor cells

However, commonly used ferroptosis modulators are often associated with significant side effects, including pulmonary toxicity (Parry et al., 2002), liver damage, and neurotoxic effects (Zaafar et al., 2024)

After each cohort, safety and tolerability data are carefully reviewed before any escalation to the next dose level is considered

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