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It causes oxidation of the polyunsaturated fatty acids membrane of brain cells (Samarghandian et al

However, the majority of neuronal CB 1 Rs are found on pre-synaptic terminals, where their primary function is to suppress the release of neurotransmitters, altering the activation of post-synaptic channels and, therefore, modulating synaptic activity and plasticity (Mackie and Hille, 1992

Electro-poration was performed at 1150 V, 30 ms pulse width, and 2 pulses for HKP1 cells and 1400 V, 20 ms pulse width, 2 pulses for B16 cells

Lab Invest 48 : 6879 Awasthi YC, Beutler E, Srivastava SK 1975 Purification and properties of human erythrocyte glutathione peroxidase

doi: 10.1001/jamapsychiatry.2022.1142, 43

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