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Additionally, DAPA reversed the altered expression of ferroptosis-related genes at both the mRNA and protein levels: The decreased expression of GPX4, SLC7A11 and FTH-1 in renal tissues of the si-Nrf2 group was improved by DAPA, while the elevated expression of TFR-1 was inhibited by DAPA (Fig

In total, three samples were prepared per group and five random fields of view were selected for each sample for observation and imaging under a transmission electron microscope

Transcriptional control of autophagy-lysosome function drives pancreatic cancer metabolism

Ero1 and redox homeostasis in the endoplasmic reticulum