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doi: 10.2967/jnumed.121.263196 78 GuerreiroR.RossO

Any concurrent medication use should be discussed with a healthcare provider who can evaluate potential interactions

Scavenges free radicals, lowers oxidative damage and inflammation

Although the precise mechanism of IGFBP-2 oncogenesis in bladder cancer (or other cancers) is unclear, it has a defined role in stimulating angiogenesis and metastasis through IGF1R as described above [40], and its reported oncogenic signaling through integrin- 1 and ERK activation [46] is consistent with the known interaction between activated IGF1R and integrin- 1 with scaffolding by RACK1 and FAK, which promotes proliferative ERK signaling as well as EMT and increased invasiveness [47] (Fig