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A critical role for increased labile zinc in reducing sensitivity of cultured sheep pulmonary artery endothelial cells to LPS-induced apoptosis

Pain 10, 71

Ferritin, a spherical iron storage protein in cells, is composed of a combination of 24 subunits of heavy-chain ferritin (ferritin-H) and light-chain ferritin (ferritin-L), which bind and sequester intracellular iron in the form of ferric ions[13, 56, 57]

This reduces its availability for the TCA cycle, limiting acetyl-CoA entry, which leads to its accumulation

Nutrition and Cancer