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After EZH2 inhibitor treatment, tumor cells undergo significant lipid metabolic reprogramming [164], activating the SLC7A11/GPX4 antioxidant axis and upregulating lipid/cholesterol synthesis-related genes (e.g., Stearoyl-CoA Desaturase 1, SCD1), thereby resisting ferroptosis and limiting the efficacy of EZH2 inhibitors

* * Technically speaking, in the USA, pimobendan remains approved by the FDA only for MVD-affected dogs already in heart failure

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Lindberg G, Rstam L, Gullberg B, Eklund GA

Several MCL1 inhibitors have currently been evaluated in clinical trials, and are one of the promising molecules for targeted AML treatment and detailed examples will be discussed below

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