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Despite etiological divergence, early-life nutritional imbalances converge on shared mechanisms and consequences with intergenerational implications

doi: 10.1021/acs.jafc.7b00899 42

Microbiome 10 , 230 (2022)

290,291,292 Accumulating macrophages release cytokines and chemokines, including IL-1, IL-6, chemokine ligand 2 (CCL2), and TNF-, intensifying the inflammatory environment and aggravating nerve damage

Selective Gsto2 knockdown prevents the early and late onset of motor symptoms in Trkb Penk -KO mice Penk -KO The above results suggest that disrupted TrkB signalling in iSPNs affects GSHascorbate metabolism, particularly GSTO2, which impacts the DA system and thus energy metabolism

I., Patrucco, L., Miguez, J., Besada, C