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10.1016/j.phymed.2020.153175 Brinza, I., Boiangiu, R.S., Cioanca, O., Hancianu, M., Dumitru, G., Hritcu, L., et al., 2023

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They also determined that IR inhibits Ferritin Heavy Chain 1 (FTH1) expression [38], once again implicating the role of iron storage disruption in IR-induced ferroptosis progression

Costunolide also improved central nervous system parameters, such as serotonin and norepinephrine levels in the hippocampus, indicating its bidirectional effects on the gut-brain axis