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Then, the right sciatic nerve was injured for 15 s and 60 s, respectively, by applying 50 N of force via forceps (Figure 2C)

One of melatonins key actions as an antioxidant is to promote the function of NrF2 [407]

These observations are consistent with, though do not prove, a role for oxidative stress in migraine pathophysiology, and are discussed below in the context of existing literature and the limitations of the present sample size