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349 Similarly, mutations in valosin-containing protein (VCP), a multifunctional AAA-ATPase essential for extracting ubiquitinated proteins from cellular structures and directing them toward degradation, cause multisystem proteinopathies that include ALS, FTD, and inclusion body myopathy

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Results showed superiority of both levodopa dose reduction regimens with opicapone adjunct in terms of significant reductions of OFF-time and increases in ON-time vs the original 500 mg/day as well as significant increases in the minimum level of levodopa plasma concentrations and area under the curve (AUC) values

Male participant (age 51) RESULTS: *The oxidative stress market F2-Isoprostane decreased by 55% in the first 14 days, maintaining a 52% decrease after 28 days

van Oostrom, S

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