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Clinical trials demonstrated that patients who followed gradual escalation experienced significantly fewer gastrointestinal side effects compared to those on faster schedules

Altogether, initial reports of NAD + precursors and exercise in clinical trials, while encouraging in certain instances, are still too inconclusive to directly link an increase in NAD + levels and mitochondrial metabolism to established health benefits in humans

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The distribution of values was tested by the one-sample KS test, and data are presented as the mean +/ SD or as median and IQR, where appropriate

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